A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4, CD152) is a receptor on T cells that inhibits the cell’s functions. Blocking CTLA-4 with an antibody has proven effective for the treatment of cancer patients. Anti-CTLA-4 antibodies currently approved for clinical use can bind to human CTLA-4, bu...

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書誌詳細

主要な著者:	Dong Li, Jing Li, Huanyu Chu, Zhuozhi Wang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Taylor & Francis Group 2020-01-01
シリーズ:	mAbs
主題:	Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) CD152 antibody cross-species binding epitope mapping N-glycosylation
オンライン･アクセス:	https://www.tandfonline.com/doi/10.1080/19420862.2020.1725365
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