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Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity

A novel series of nitrostyrene-based spirooxindoles were synthesized via the reaction of substituted isatins <b>1a</b>–<b>b</b>, a number of α-amino acids <b>2a</b>–<b>e</b> and (E)-2-aryl-1-nitroethenes <b>3a</b>–<b>e</b> in a chemo/regio-selective manner using [3+2] cycloaddition (Huisgen) reactio...

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Hoofdauteurs: Richa Sharma, Lalit Yadav, Ali Adnan Nasim, Ravi Kant Yadav, Rui Hong Chen, Neha Kumari, Fan Ruiqi, Ashoke Sharon, Nawal Kishore Sahu, Sirish Kumar Ippagunta, Paolo Coghi, Vincent Kam Wai Wong, Sandeep Chaudhary
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2023-09-01
Reeks:Molecules
Onderwerpen:
anticancer
spirooxindole
[3+2] cycloaddition
azomethine ylide
microwave
Online toegang:https://www.mdpi.com/1420-3049/28/18/6503
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