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Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue

Objectives: Understanding how loci identified by genome wide association studies (GWAS) contribute to pathogenesis requires new mechanistic insights. Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and obesity. Investigations in mouse models have focused...

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Автори: Colin J. Palmer, Raphael J. Bruckner, Joao A. Paulo, Lawrence Kazak, Jonathan Z. Long, Amir I. Mina, Zhaoming Deng, Katherine B. LeClair, Jessica A. Hall, Shangyu Hong, Peter-James H. Zushin, Kyle L. Smith, Steven P. Gygi, Susan Hagen, David E. Cohen, Alexander S. Banks
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2017-10-01
Серія:Molecular Metabolism
Предмети:
Cdkal1
GWAS
Diabetes
Adipose
Mitochondria
ANT1
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2212877817304532
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