HiDeF: identifying persistent structures in multiscale ‘omics data

Abstract In any ‘omics study, the scale of analysis can dramatically affect the outcome. For instance, when clustering single-cell transcriptomes, is the analysis tuned to discover broad or specific cell types? Likewise, protein communities revealed from protein networks can vary widely in sizes dep...

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Autors principals:	Fan Zheng, She Zhang, Christopher Churas, Dexter Pratt, Ivet Bahar, Trey Ideker
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2021-01-01
Col·lecció:	Genome Biology
Matèries:	Systems biology Multiscale Persistent homology Community detection Resolution Single-cell clustering
Accés en línia:	https://doi.org/10.1186/s13059-020-02228-4
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