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Natural product mediated mesenchymal–epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA

The transition of cancer cells from epithelial state to mesenchymal state awarded hepatocellular carcinoma (HCC) stem cell properties and induced tumorigenicity, drug resistance, and high recurrence rate. Reversing the mesenchymal state to epithelial state by inducing mesenchymal–epithelial remodeli...

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Main Authors: Tianyang Chen, Guangju Liu, Sisi Chen, Fengyuan Zhang, Shuoqian Ma, Yongping Bai, Quan Zhang, Yahui Ding
Format: Artigo
Language:Inglês
Published: Elsevier 2025-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Natural product
Target identification
ENO1
Mesenchymal‒epithelial remodeling
β-Catenin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524002879
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