Cryopreservable dopaminergic progenitors derived from human iPSCs with accelerated loss of pluripotency and early functional restoration in Parkinsonian rats

Abstract Midbrain dopaminergic progenitors (mDAp) derived from human pluripotent stem cells have demonstrated promising safety and efficacy in Phase I clinical transplantation trials for Parkinson’s disease (PD). To further improve the translational potential of this approach, strategies that accele...

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Autori principali:	Chia-Yu Chang, Cheng-Yun Chiang, Hsiao-Chien Ting, Yung-Jen Tsai, Po-Chiang Chan, Mei-Fang Chen, Yun-Ting Guo, Yuan-Hsuan Liu, Yu-Shuan Chen, Chi-Hsuan Chuang, Po-Cheng Lin, Lin-Hsiang Chuang, Mao-Hsuan Huang, Yi-Chung Tung, Po-Yi Chen, Horng-Jyh Harn, Hong-Lin Su, Shinn-Zong Lin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-05-01
Serie:	npj Parkinson's Disease
Accesso online:	https://doi.org/10.1038/s41531-026-01399-4
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