The dynamic changes of X chromosome inactivation during early culture of human embryonic stem cells

X chromosome inactivation (XCI) is required for dosage compensation of X-linked genes in human female cells. Several previous reports have described the promiscuous XCI status in long-term cultured female human embryonic stem cells (hESCs), and the majority of them exhibit non-random XCI. However, w...

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Detalhes bibliográficos

Principais autores:	Pingyuan Xie, Qi Ouyang, Lizhi Leng, Liang Hu, Dehua Cheng, Yueqiu Tan, Guangxiu Lu, Ge Lin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-07-01
coleção:	Stem Cell Research
Assuntos:	Human embryonic stem cells X chromosome inactivation Epigenetics Gene expression regulation Culture alteration
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1873506116300496
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