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MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1

Abstract Background Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplantation, known as hypertrophic degeneration, remains the major obstacle...

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Principais autores: Svitlana Melnik, Jessica Gabler, Simon I. Dreher, Nicole Hecht, Nina Hofmann, Tobias Großner, Wiltrud Richter
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-12-01
Serier:Stem Cell Research & Therapy
Fag:
miR-218
Mesenchymal stromal cells (MSC)
Chondrocyte hypertrophy
Osteoarthritis (OA)
MEF2C
RUNX2
Online adgang:https://doi.org/10.1186/s13287-020-02026-6
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