Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells

<p>Abstract</p> <p>Background</p> <p>Hypoxia-inducible factor-1 (HIF-1) overexpression has been linked to tumor progression and poor prognosis. We investigated whether targeting of HIF-1 using chetomin, a disrupter of the interaction of HIF-1 with the transcriptional coactivator p300, influences the...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Baier Kurt, Schwab Franz, Fleischer Markus, Beyer Melanie, Katzer Astrid, Diehlmann Désirée, Said Harun M, Loeffler Jürgen, Staab Adrian, Einsele Hermann, Flentje Michael, Vordermark Dirk
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2007-11-01
Schriftenreihe:	BMC Cancer
Online-Zugang:	http://www.biomedcentral.com/1471-2407/7/213
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