Generation of bone-specific lysyl hydroxylase 2 knockout mice and their phenotypes

Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the telopeptides of type I collagen. This modification is critical for the formation of stable hydroxylysine-aldehyde derived collagen cross-links, thus, for the stability of collagen fibrils. Though dysfunction of LH2 cause...

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Autors principals:	Kenta Tsuneizumi, Atsushi Kasamatsu, Tomoaki Saito, Reo Fukushima, Yuki Taga, Kazunori Mizuno, Masataka Sunohara, Katsuhiro Uzawa, Mitsuo Yamauchi
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-09-01
Col·lecció:	Biochemistry and Biophysics Reports
Matèries:	Lysyl hydroxylase 2 Collagen cross-link Bone-specific conditional knockout
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2405580824001547
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