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HIF-1α dependent RhoA as a novel therapeutic target to regulate rheumatoid arthritis fibroblast-like synoviocytes migration in vitro and in vivo

Objective: The purpose of this work is to investigate how the Rho family of GTPases A (RhoA) mediates the pathogenesis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Methods: The expression of RhoA in the synovial tissues of RA and Healthy people (Control) was detected using immunohi...

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Principais autores: Jianhai Chen, Jingqin Chen, Jianwei Tan, Jian Li, Wenxiang Cheng, Liqing Ke, Qijing Wang, Anqiao Wang, Sien Lin, Gang Li, Peng Zhang, Benguo Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-05-01
coleção:Journal of Orthopaedic Translation
Assuntos:
Hypoxia
RhoA
Migration
Rheumatoid arthritis
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2214031X23000311
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