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Toward Therapeutic Drug Monitoring of Lenalidomide in Hematological Malignancy? Results of an Observational Study of the Exposure-Safety Relationship

Objective: Continuous lenalidomide (LEN) therapy is important to achieve a therapeutic effect in patients with multiple myeloma (MM) and non-Hodgkin lymphoma (NHL). However, despite dose adjustment according to kidney function, many patients discontinue LEN therapy because of hematological toxicity....

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Principais autores: Zaiwei Song, Lan Ma, Li Bao, Yi Ma, Ping Yang, Dan Jiang, Aijun Liu, Lu Zhang, Yan Li, Yinchu Cheng, Fei Dong, Rongsheng Zhao, Hongmei Jing
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-06-01
Serier:Frontiers in Pharmacology
Fag:
lenalidomide
hematological toxicity
therapeutic drug monitoring
trough concentration
hematological malignancies
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2022.931495/full
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