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The Amino-Terminal Region of Hepatitis E Virus ORF1 Containing a Methyltransferase (Met) and a Papain-Like Cysteine Protease (PCP) Domain Counteracts Type I Interferon Response

Hepatitis E virus (HEV) is responsible for large waterborne epidemics of hepatitis in endemic countries and is an emerging zoonotic pathogen worldwide. In endemic regions, HEV-1 or HEV-2 genotypes are frequently associated with fulminant hepatitis in pregnant women, while with zoonotic HEV (HEV-3 an...

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Principais autores: Eugénie Bagdassarian, Virginie Doceul, Marie Pellerin, Antonin Demange, Léa Meyer, Nolwenn Jouvenet, Nicole Pavio
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2018-12-01
Series:Viruses
Assuntos:
hepatitis E virus
innate immunity
interferon response
JAK/STAT pathway
zoonosis
emerging pathogen
Acceso en liña:https://www.mdpi.com/1999-4915/10/12/726
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