D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice

To test the hypothesis that intestine is a major site of action for D-4F, LDLR−/− mice were fed a Western diet (WD) and administered the peptide subcutaneously (SQ) or orally. Plasma and liver D-4F levels were 298-fold and 96-fold higher, respectively, after SQ administration, whereas peptide levels...

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Autori principali:	Mohamad Navab, Srinivasa T. Reddy, G.M. Anantharamaiah, Greg Hough, Georgette M. Buga, Jan Danciger, Alan M. Fogelman
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2012-03-01
Serie:	Journal of Lipid Research
Soggetti:	apolipoprotein A-I apolipoprotein A-I mimetic peptides lipoproteins hydroxyeicosatetraenoic acid hydroxyoctadecadienoic acid small intestine
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0022227520413598
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