RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs

Abstract Background RNA secondary structures in the 5′-untranslated regions (5′-UTR) of mRNAs are key to the post-transcriptional regulation of gene expression. While it is evident that non-canonical Hoogsteen-paired G-quadruplex (rG4) structures somehow contribute to the regulation of translation i...

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Bibliografische gegevens

Hoofdauteurs:	Pierre Murat, Giovanni Marsico, Barbara Herdy, Avazeh Ghanbarian, Guillem Portella, Shankar Balasubramanian
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2018-12-01
Reeks:	Genome Biology
Onderwerpen:	Translation regulation RNA secondary structures G-quadruplexes Helicases Upstream open reading frames
Online toegang:	http://link.springer.com/article/10.1186/s13059-018-1602-2
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