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TopoQual polishes circular consensus sequencing data and accurately predicts quality scores

Abstract Background Pacific Biosciences (PacBio) circular consensus sequencing (CCS), also known as high fidelity (HiFi) technology, has revolutionized modern genomics by producing long (10 + kb) and highly accurate reads. This is achieved by sequencing circularized DNA molecules multiple times and...

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Principais autores: Minindu Weerakoon, Sangjin Lee, Emily Mitchell, Haynes Heaton
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-01-01
Serier:BMC Bioinformatics
Fag:
Topoqual
Deep consensus
Pacbio
Circular consensus sequencing
High fidelity
Somatic mutations
Online adgang:https://doi.org/10.1186/s12859-024-06020-0
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