Pharmacokinetics of diclofenac in healthy controls with wild-type phenotype for CYP2C9 shows metabolism variability
Background: Cytochrome P450 2C9 (CYP2C9) is an important enzyme in the metabolism of many drugs, including NSAIDs, antidepressants and anticoagulants. In vitro and in vivo studies have demonstrated that CYP2C9 polymorphisms modify the activity of the enzyme and subsequently the metabolism of differe...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
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2017-04-01
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| Serie: | Revista Médica del Hospital General de México |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S0185106317300021 |
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