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Induction of TRIM22 promotes autophagy and apoptosis of colorectal cancer through reactive oxygen species generation

Abstract Background Colorectal cancer (CRC) is one of the most common causes of cancer-associated death worldwide, and a rapid increase in the incidence and mortality of CRC has been predicted with a marked trend in the younger age group. Therefore, identifying novel therapeutic targets and developi...

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Main Authors: Xiaoxuan Ma, Radhakrishnam Raju Ruddarraju, Yibing Li, Bingyan Shen, Haizhen Liu, Chaochao Ge, Naixin Peng, Lei Gao, Chaojie Wang, Guoyu Zhang, Fujun Dai, Xinrui Lv
Format: Artigo
Language:Inglês
Published: BMC 2026-02-01
Series:Journal of Translational Medicine
Subjects:
TRIM22
ROS
Autophagy
Apoptosis
Colorectal cancer
Online Access:https://doi.org/10.1186/s12967-026-07839-2
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