Signal transduction pathways (MAPKs, NF-κB, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance.

BACKGROUND: Recent studies have revealed that cyclooxygenase-2 (COX-2) expression is down-regulated in aspirin-induced asthma (AIA). Various signal pathways (MAPKs, NF-κB and C/EBP) are involved in COX-2 regulation. OBJECTIVE: To investigate the regulation of COX-2 expression through MAP-kinase path...

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Principais autores:	Francesc Josep Garcia-Garcia, Joaquim Mullol, Maria Perez-Gonzalez, Laura Pujols, Isam Alobid, Jordi Roca-Ferrer, Cesar Picado
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2012-01-01
Colecção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC3519844?pdf=render
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