Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors
Abstract Recombinant adeno-associated viral vectors (rAAV) are a powerful tool for gene delivery but have a limited DNA carrying capacity. Efforts to expand this genetic payload have focused on engineering the vector components, such as dual trans-splicing vectors which double the delivery size by e...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2025-02-01
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| Collection: | Nature Communications |
| Accès en ligne: | https://doi.org/10.1038/s41467-025-56738-5 |
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