Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis

ObjectiveTo analyze differences in gut microbiota composition, metabolites, and metabolic pathways between healthy individuals and colorectal cancer (CRC) patients, and to investigate the inhibitory effects of N-methylserotonin (NMS) produced by Bacteroides ovatus (B.o) from orange fiber on CRC prog...

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Hlavní autoři:	Jikai He, Jiaqi Jia, Wenhao Qu, Shuyu Zhang, Keyu Fan, Runze Lin, Wei Zhao, Yan Niu, Yanqiang Huang, Lizhou Jia
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-11-01
Edice:	Frontiers in Immunology
Témata:	N-methylserotonin bacteroides ovatus colorectal cancer gut microbiota metabolites
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1696701/full
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