Novel small molecule inhibitor of GPR68 attenuates endothelial dysfunction and lung injury caused by bacterial lipopolysaccharide

Abstract The treatment of acute respiratory distress syndrome (ARDS) associated with high mortality remains a major global clinical challenge. Role of pulmonary endothelial dysfunction in uncontrolled lung inflammation and alveolar flooding is increasingly recognized. GPR68 is a member of proton-sen...

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Bibliografische gegevens

Hoofdauteurs:	Pratap Karki, Yunbo Ke, Chen-Ou Zhang, Kamoltip Promnares, Yue Li, Charles H. Williams, Konstantin G. Birukov, Charles C. Hong, Anna A. Birukova
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Nature Portfolio 2025-11-01
Reeks:	Scientific Reports
Onderwerpen:	Endothelial permeability Lung injury Inflammation LPS CRX-527 GPR68
Online toegang:	https://doi.org/10.1038/s41598-025-02582-y
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