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Probe-specific mixed-model approach to detect copy number differences using multiplex ligation-dependent probe amplification (MLPA)

<p>Abstract</p> <p>Background</p> <p>MLPA method is a potentially useful semi-quantitative method to detect copy number alterations in targeted regions. In this paper, we propose a method for the normalization procedure based on a non-linear mixed-model, as well as a new approach for determining the...

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Principais autores: Villatoro Sergi, Armengol Lluís, Carrasco Josep L, González Juan R, Jover Lluís, Yasui Yutaka, Estivill Xavier
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2008-06-01
Serier:BMC Bioinformatics
Online adgang:http://www.biomedcentral.com/1471-2105/9/261
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