Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism.

Increased pain sensitivity after opioid administration (opioid-induced hyperalgesia) and/or repeated painful stimuli is an individually varying and clinically important phenomenon. The functional polymorphism (val(158)met) of the Catechol-O-methyltransferase (COMT) gene regulates the metabolism of d...

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Detalhes bibliográficos

Principais autores:	Karin B Jensen, Tina B Lonsdorf, Martin Schalling, Eva Kosek, Martin Ingvar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2009-06-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC2695541?pdf=render
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