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Deciphering the carcinogenic role of benzo[a]pyrene in glioblastoma: Insights from network toxicology, single-cell transcriptomics, and Mendelian randomization

Background: Benzo[a]pyrene (BaP) is a known environmental carcinogen linked to multiple tumors, but its role in glioblastoma (GBM) remains poorly understood. This study aimed to explore BaP’s tumorigenic mechanisms in GBM through an integrated approach combining network toxicology, single-cell trans...

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Principais autores: Liye Yi, Wencai Wang, Zhonghua Sun, Yinuo Chen, Zijie Xiong, Luyao Ma, Wei Ye, Xianfeng Li
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-10-01
coleção:Ecotoxicology and Environmental Safety
Assuntos:
Benzo[a]pyrene
Glioblastoma
Network toxicology
Single-cell transcriptomics
Mendelian randomization
Bibliometric analysis
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0147651325015003
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