HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing data

Abstract Bulk DNA sequencing of multiple samples from the same tumor is becoming common, yet most methods to infer copy-number aberrations (CNAs) from this data analyze individual samples independently. We introduce HATCHet2, an algorithm to identify haplotype- and clone-specific CNAs simultaneously...

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Hlavní autoři:	Matthew A. Myers, Brian J. Arnold, Vineet Bansal, Metin Balaban, Katelyn M. Mullen, Simone Zaccaria, Benjamin J. Raphael
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-05-01
Edice:	Genome Biology
Témata:	Copy-number aberrations Cancer Genomics Tumor heterogeneity Clone Allele-specific
On-line přístup:	https://doi.org/10.1186/s13059-024-03267-x
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