Subgroup analysis methods for time-to-event outcomes in heterogeneous randomized controlled trials

Abstract Background Non-significant randomized controlled trials can hide subgroups of good responders to experimental drugs, thus hindering subsequent development. Identifying such heterogeneous treatment effects is key for precision medicine and many post-hoc analysis methods have been developed f...

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Detalhes bibliográficos

Principais autores:	Valentine Perrin, Nathan Noiry, Nicolas Loiseau, Alex Nowak
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	BMC Medical Research Methodology
Assuntos:	Benchmarking Heterogeneity Randomized controlled trials Subgroup analysis Time-to-event
Acesso em linha:	https://doi.org/10.1186/s12874-026-02794-4
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