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Werner helicase interacting protein 1 contributes to G-quadruplex processing in human cells

Abstract Genome replication is frequently impeded by highly stable DNA secondary structures, including G-quadruplex (G4) DNA, that can hinder the progression of the replication fork. Human WRNIP1 (Werner helicase Interacting Protein 1) associates with various components of the replication machinery...

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Huvudupphov: Lili Hegedus, Agnes Toth, Gabor M. Harami, Janos Palinkas, Nargis Karatayeva, Eniko Sajben-Nagy, Szabolcs Bene, Sara Afzali Jaktajdinani, Mihaly Kovacs, Szilvia Juhasz, Peter Burkovics
Materialtyp: Artigo
Språk:Inglês
Utgiven: Nature Portfolio 2024-07-01
Serie:Scientific Reports
Ämnen:
WRNIP1
G-quadruplex
PIF1
DNA helicase
Genome stability
Replication
Länkar:https://doi.org/10.1038/s41598-024-66425-y
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