SPARCL1 promotes chondrocytes extracellular matrix degradation and inflammation in osteoarthritis via TNF/NF-κB pathway

Objectives: SPARCL1 is a matricellular protein that mediates the cell–matrix interactions and participates in physiological processes such as cell adhesion, differentiation and proliferation. However, its role in chondrocyte and osteoarthritis (OA) progression has not been fully characterized. We ai...

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Bibliografische Detailangaben

Hauptverfasser:	Yu Miao, Shenghui Wu, Ziling Gong, Yiwei Chen, Feng Xue, Kexin Liu, Jian Zou, Yong Feng, Guangyi Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-05-01
Schriftenreihe:	Journal of Orthopaedic Translation
Schlagworte:	ECM degradation Osteoarthritis SPARCL1 TNF/NF-κB
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2214031X24000287
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