Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis

Background Checkpoint inhibitor-induced hepatitis (CPI-hepatitis) is an emerging problem with the widening use of CPIs in cancer immunotherapy. Here, we developed a mouse model to characterize the mechanism of CPI-hepatitis and to therapeutically target key pathways driving this pathology.Methods C5...

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Autori principali:	Nick Powell, Mark R Thursz, Kevin J Woollard, James Larkin, Samra Turajlic, Stephen R Atkinson, Robert D Goldin, Evangelos Triantafyllou, Lucia A Possamai, Charalambos G Antoniades, Cathrin L C Gudd, Eoin Mitchell, Marie-Anne Mawhin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMJ Publishing Group 2024-04-01
Serie:	Journal for ImmunoTherapy of Cancer
Accesso online:	https://jitc.bmj.com/content/12/4/e008078.full
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Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis

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