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<named-content content-type="genus-species">Toxoplasma gondii</named-content> Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon

ABSTRACT Toxoplasma gondii evades host immunity to establish a chronic infection. Here, we assessed the role of parasitophorous vacuole (PV) membrane (PVM)- and intravacuolar network (IVN) membrane-localized dense granule (GRA) proteins in the development of acute and chronic Toxoplasma infection. D...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Barbara A. Fox, Rebekah B. Guevara, Leah M. Rommereim, Alejandra Falla, Valeria Bellini, Graciane Pètre, Camille Rak, Viviana Cantillana, Jean-François Dubremetz, Marie-France Cesbron-Delauw, Gregory A. Taylor, Corinne Mercier, David J. Bzik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019-08-01
Schriftenreihe:mBio
Schlagworte:
Toxoplasma gondii
chronic infection
dense granule
innate immunity
membrane proteins
virulence factors
Online-Zugang:https://journals.asm.org/doi/10.1128/mBio.00589-19
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