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Ideal vs. real: a systematic review on handling covariates in randomized controlled trials

Abstract Background In theory, efficient design of randomized controlled trials (RCTs) involves randomization algorithms that control baseline variable imbalance efficiently, and corresponding analysis involves pre-specified adjustment for baseline covariates. This review sought to explore technique...

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Principais autores: Jody D. Ciolino, Hannah L. Palac, Amy Yang, Mireya Vaca, Hayley M. Belli
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-07-01
Serier:BMC Medical Research Methodology
Fag:
Randomization
Allocation
Stratification
Minimization
CONSORT
Online adgang:http://link.springer.com/article/10.1186/s12874-019-0787-8
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