xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade

Abstract Colorectal cancer (CRC) is one of the most commonly diagnosed and deadly malignant tumors globally, and its occurrence and progression are closely related to the poor histological features and complex molecular characteristics among patients. It is urgent to identify specific biomarkers for...

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Detalhes bibliográficos

Principais autores:	Bufu Tang, Jinyu Zhu, Fangming Liu, Jiayi Ding, Yajie Wang, Shiji Fang, Liyun zheng, Rongfang Qiu, Minjiang Chen, Gaofeng Shu, Min Xu, Chenying Lu, Zhongwei Zhao, Yang Yang, Jiansong Ji
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2022-04-01
coleção:	Cell Death and Disease
Acesso em linha:	https://doi.org/10.1038/s41419-022-04827-4
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