Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice

The emergence of new immune-evasive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and subvariants outpaces the development of vaccines specific against the dominant circulating strains. In terms of the only accepted immune correlate of protection, the inactivated whole-virion...

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Автори:	Jian-Piao Cai, Cuiting Luo, Kun Wang, Hehe Cao, Lin-Lei Chen, Xiaojuan Zhang, Yuting Han, Feifei Yin, Anna Jinxia Zhang, Hin Chu, Shuofeng Yuan, Kin-Hang Kok, Kelvin Kai-Wang To, Honglin Chen, Zhiwei Chen, Dong-Yan Jin, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2023-03-01
Серія:	Viruses
Предмети:	COVID-19 SARS-CoV-2 Omicron variant BA.5.2 XBB.1 Fc-RBD
Онлайн доступ:	https://www.mdpi.com/1999-4915/15/3/687
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