Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

<p>Abstract</p> <p>Background</p> <p>Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysacch...

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Bibliografski detalji

Glavni autori:	Kovarik Pavel, Stiefvater Rita, Wallner Barbara, Hofmann Elisabeth, Fuhrmann Bernd, Flatt Thomas, Vogl Claus, Strobl Birgit, Müller Mathias
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2010-03-01
Serija:	BMC Genomics
Online pristup:	http://www.biomedcentral.com/1471-2164/11/199
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