Enhanced Expression of the <i>L1R</i> Gene of Vaccinia Virus by the tPA Signal Sequence Inserted in a Fowlpox-Based Recombinant Vaccine

The use of Vaccinia virus (VACV) as a preventive vaccine against variola, the etiological agent of smallpox, led to the eradication of smallpox as a human disease. The L1 protein, a myristylated transmembrane protein present on the surface of mature virions, plays a significant role in infection and...

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Principais autores:	Antonia Radaelli, Carlo Zanotto, Chiara Brambilla, Tommaso Adami, Carlo De Giuli Morghen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-09-01
coleção:	Vaccines
Assuntos:	tissue plasminogen activator signal sequence (tPA) vaccinia virus L1 protein monkeypox virus fowlpox virus recombinant vaccines immunogenicity enhancement
Acesso em linha:	https://www.mdpi.com/2076-393X/12/10/1115
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