The E3 ubiquitin ligase RNF180 modulates the EGFR/PI3K/AKT pathway to reduce cisplatin resistance in non-small cell lung cancer

Abstract Non-small cell lung cancer (NSCLC) is recognized as one of the most aggressive cancers, and resistance to cisplatin significantly hinders effective clinical treatment. The role of the E3 ubiquitin ligase RNF180 in cisplatin resistance in NSCLC remains unclear. A549/DDP cells were transduced...

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Autors principals:	Xiaoyan Song, Wen Jiang, Hongxuan Wei, Yan Zhu, Junmei Shu, Chuandong Zhu, Fangfang Chen
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-03-01
Col·lecció:	Scientific Reports
Matèries:	Non-small cell lung cancer Cisplatin resistance E3 ubiquitin ligase RNF180 EGFR/PI3K/AKT
Accés en línia:	https://doi.org/10.1038/s41598-026-41718-6
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