Proteasomal-dependent CHK1 degradation leads to DNA damage accumulation in ALS cellular model systems

Abstract Amyotrophic lateral sclerosis (ALS) is characterised by the aggregation of TDP-43 and mutant FUS in the cytoplasm of affected motor neurons. Accumulation of DNA damage is emerging as a novel correlative trait of ALS. We recently showed that formation of TDP-43 and FUS cytoplasmic inclusions...

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Principais autores:	Stefania Modafferi, Valentina Silenzi, Anna Garbelli, Gloria Lazoi, Eveljn Scarian, Sara D’Uva, Tiziana Santini, Adelaide Riccardi, Mauro Cozzolino, Orietta Pansarasa, Nadia D’Ambrosi, Simone Sabbioneda, Mariangela Morlando, Sofia Francia
格式:	Artigo
語言:	Inglês
出版:	Nature Publishing Group 2026-05-01
叢編:	Cell Death and Disease
在線閱讀:	https://doi.org/10.1038/s41419-026-08603-6
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