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Modelling the structures of frameshift-stimulatory pseudoknots from representative bat coronaviruses.

Coronaviruses (CoVs) use -1 programmed ribosomal frameshifting stimulated by RNA pseudoknots in the viral genome to control expression of enzymes essential for replication, making CoV pseudoknots a promising target for anti-coronaviral drugs. Bats represent one of the largest reservoirs of CoVs and...

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Autori principali: Rohith Vedhthaanth Sekar, Patricia J Oliva, Michael T Woodside
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2023-05-01
Serie:PLoS Computational Biology
Accesso online:https://doi.org/10.1371/journal.pcbi.1011124
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