Synaptic and cytoskeletal CSF signatures of motor neuron disease: the role of cyclase-associated protein 2

Abstract Cyclase-associated protein 2 (CAP2) is a synaptic actin-binding protein involved in cofilin-mediated spine remodelling, Alzheimer’s Disease synaptic failure and myofibril maintenance, indicating its potential involvement in motor neuron disease (MND). This study examined cerebrospinal fluid...

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Detalhes bibliográficos

Principais autores:	Andrea Pilotto, Silvia Pelucchi, Chiara Trasciatti, Lucia Ferullo, Loris Poli, Chiara Tolassi, Alberto Catanese, Irene Girotto, Beatrice Labella, Federica Gorla, Laura D’Andrea, Ramona Stringhi, Monica Di Luca, Elena Marcello, Alessandro Padovani
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-02-01
coleção:	Scientific Reports
Assuntos:	Motor neuron disease (MND) Synaptic biomarkers Neurofilament light chain (NfL) Cerebrospinal fluid (CSF)
Acesso em linha:	https://doi.org/10.1038/s41598-026-39274-0
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