Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease

Clinical evidence suggests that the entorhinal cortex is a primary brain area triggering memory impairments in Alzheimer’s disease (AD), but the underlying brain circuit mechanisms remain largely unclear. In healthy brains, sharp-wave ripples (SWRs) in the hippocampus and entorhinal cortex play a cr...

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Hlavní autoři:	Tsukasa Funane, Heechul Jun, Stephanie Sutoko, Takaomi C. Saido, Akihiko Kandori, Kei M. Igarashi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-08-01
Edice:	Frontiers in Systems Neuroscience
Témata:	Alzheimer’s disease hippocampus entorhinal cortex medial entorhinal cortex (MEC) sharp-wave ripples (SWRs)
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnsys.2022.955178/full
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