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Super-complexes of adhesion GPCRs and neural guidance receptors

FLRT proteins are known to interact with Lphns and Unc5s, mediating cell adhesion and repulsion respectively. Here the authors use crystallography, native mass spectrometry, molecular dynamics simulations and cell-based assays to show that these three proteins form large super-complexes with functio...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Verity A. Jackson, Shahid Mehmood, Matthieu Chavent, Pietro Roversi, Maria Carrasquero, Daniel del Toro, Goenuel Seyit-Bremer, Fanomezana M. Ranaivoson, Davide Comoletti, Mark S. P. Sansom, Carol V. Robinson, Rüdiger Klein, Elena Seiradake
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2016-04-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/ncomms11184
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