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Alpha-Synuclein Gene Alterations Modulate Tyrosine Hydroxylase in Human iPSC-Derived Neurons in a Parkinson’s Disease Animal Model

Parkinson’s disease (PD) caused by <i>SNCA</i> gene triplication (3X<i>SNCA</i>) leads to early onset, rapid progression, and often dementia. Understanding the impact of 3X<i>SNCA</i> and its absence is crucial. This study investigates the differentiation of human induced pluripotent stem cell (hiPS...

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Autors principals: Luis Daniel Bernal-Conde, Verónica Peña-Martínez, C. Alejandra Morato-Torres, Rodrigo Ramos-Acevedo, Óscar Arias-Carrión, Francisco J. Padilla-Godínez, Alexa Delgado-González, Marcela Palomero-Rivero, Omar Collazo-Navarrete, Luis O. Soto-Rojas, Margarita Gómez-Chavarín, Birgitt Schüle, Magdalena Guerra-Crespo
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2024-06-01
Col·lecció:Life
Matèries:
alpha-synuclein
dopaminergic neurons
human induced pluripotent stem cells
cell transplant
6-OHDA
Parkinson’s disease
Accés en línia:https://www.mdpi.com/2075-1729/14/6/728
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