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Multiplex immunohistochemistry defines the tumor immune microenvironment and immunotherapeutic outcome in CLDN18.2-positive gastric cancer

Abstract Background The FAST study identified claudin-18 (CLDN18.2) as a promising novel therapeutic target for gastric cancer (GC). However, the tumor immune microenvironment and clinicopathological features of CLDN18.2-positive GC are unclear, making it difficult to develop and optimize CLDN18.2-t...

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Wedi'i Gadw mewn:
Prif Awduron: Keren Jia, Yang Chen, Yu Sun, Yajie Hu, Lei Jiao, Jie Ma, Jiajia Yuan, Changsong Qi, Yanyan Li, Jifang Gong, Jing Gao, Xiaotian Zhang, Jian Li, Cheng Zhang, Lin Shen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2022-07-01
Cyfres:BMC Medicine
Pynciau:
Gastric cancer
CLDN18.2
Tumor microenvironment
Immune cell
Prognosis
Mynediad Ar-lein:https://doi.org/10.1186/s12916-022-02421-1
Tagiau: Ychwanegu Tag
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