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A novel nanobody-based immunocytokine of a mutant interleukin-2 as a potential cancer therapeutic

Abstract The immunotherapeutic application of interleukin-2 (IL-2) in cancer treatment is limited by its off-target effects on different cell populations and insufficient activation of anti-tumor effector cells at the site of the tumor upon tolerated doses. Targeting IL-2 to the tumor microenvironme...

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Principais autores: Arezoo Beig Parikhani, Rada Dehghan, Yeganeh Talebkhan, Elham Bayat, Alireza Biglari, Mohammad Ali Shokrgozar, Reza Ahangari Cohan, Esmat Mirabzadeh, Soheila Ajdary, Mahdi Behdani
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2024-02-01
coleção:AMB Express
Assuntos:
Immunotherapy
Immunocytokine
Mutant IL-2
VEGFR2
Nanobody
Acesso em linha:https://doi.org/10.1186/s13568-023-01648-2
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