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The Activation of the LIMK/Cofilin Signaling Pathway via Extracellular Matrix–Integrin Interactions Is Critical for the Generation of Mature and Vascularized Cardiac Organoids

The generation of mature and vascularized human pluripotent stem cell-derived cardiac organoids (hPSC-COs) is necessary to ensure the validity of drug screening and disease modeling. This study investigates the effects of cellular aggregate (CA) stemness and self-organization on the generation of ma...

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Principais autores: Ji-Min Noh, Seung-Cheol Choi, Myeong-Hwa Song, Kyung Seob Kim, Seongmin Jun, Jae Hyoung Park, Ju Hyeon Kim, Kyoungmi Kim, Tae Hee Ko, Jong-Il Choi, Jeong-An Gim, Jong-Hoon Kim, Yongjun Jang, Yongdoo Park, Ji Eun Na, Im Joo Rhyu, Do-Sun Lim
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-08-01
Serier:Cells
Fag:
cardiac organoids
mature cardiac organoids
vascularized cardiac organoids
LIMK/Cofilin signaling
Online adgang:https://www.mdpi.com/2073-4409/12/16/2029
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