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Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma

Ascomylactam C (AsC) is a new 13-membered-ring macrocyclic alkaloid, which was first isolated and identified in 2019 from the secondary metabolites of the mangrove endophytic fungus <i>Didymella</i> sp. CYSK-4 in the South China Sea. AsC has been found to have a broad-spectrum cytotoxic activity. Ho...

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Principais autores: Yun Huang, Hongmei Yan, Bingzhi Zhang, Ge Zhu, Jianchen Yu, Xuhan Xiao, Wenxuan He, Yan Chen, Xiaoxia Gao, Zhigang She, Mengfeng Li, Jie Yuan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-11-01
Serier:Marine Drugs
Fag:
ascomylactam C
lung cancer
melanoma
endoplasmic reticulum stress
oxidative stress
immunogenic cell death
Online adgang:https://www.mdpi.com/1660-3397/21/12/600
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