Upregulated beta-defensin-1 in murine and human biliary atresia associates with human native liver survival

Abstract Biliary atresia (BA) is a neonatal cholangiopathy that often progresses to cirrhosis despite timely Kasai portoenterostomy (KPE), and prognostic biomarkers remain undefined. Given its role in adult cholestasis, we evaluated human beta-defensin-1 (hBD1) in murine and human BA for association...

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Autores principales:	Christoph Slavetinsky, Jule Basenach, Pascal Damm, Caterina Bertolini, Maximilian Holweg, Steffen Hartleif, Johannes Hilberath, Stephan Singer, Claus Petersen, Jörg Fuchs, Ekkehard Sturm
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-03-01
Colección:	Scientific Reports
Materias:	Biliary atresia Defensins hBD1 Pediatric cholestatic diseases
Acceso en línea:	https://doi.org/10.1038/s41598-026-43602-9
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