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Lenvatinib inhibits the growth of gastric cancer patient-derived xenografts generated from a heterogeneous population

Abstract Background Lenvatinib is a multitargeted tyrosine kinase inhibitor that is being tested in combination with immune checkpoint inhibitors to treat advanced gastric cancer; however, little data exists regarding the efficacy of lenvatinib monotherapy. Patient-derived xenografts (PDX) are estab...

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Bibliografiske detaljer
Principais autores: John D. Karalis, Lynn Y. Yoon, Suntrea T. G. Hammer, Changjin Hong, Min Zhu, Ibrahim Nassour, Michelle R. Ju, Shu Xiao, Esther C. Castro-Dubon, Deepak Agrawal, Jorge Suarez, Scott I. Reznik, John C. Mansour, Patricio M. Polanco, Adam C. Yopp, Herbert J. Zeh, Tae Hyun Hwang, Hao Zhu, Matthew R. Porembka, Sam C. Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-03-01
Serier:Journal of Translational Medicine
Fag:
Online adgang:https://doi.org/10.1186/s12967-022-03317-7
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