Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region.
The T cell receptor (TCR-CD3) initiates T cell activation by binding to peptides of Major Histocompatibility Complexes (pMHC). The TCR-CD3 topology is well understood but the arrangement and dynamics of its cytoplasmic tails remains unknown, limiting our grasp of the signalling mechanism. Here, we u...
Salvato in:
| Autori principali: | , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2021-07-01
|
| Serie: | PLoS Computational Biology |
| Accesso online: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009232&type=printable |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|